Today, despite advances in tissue typing and the development of suppressive drugs, it is still not possible to have skin homografts survive for prolonged periods of time. However, only two types of homograft have been successful; the one is skin homograft between monozygotic twins, the other is skin homograft upon recipients with agammaglobulinemia. It is well known that the circulatory reestablishment of homografts take place during postoperative 4th day same as autograft, however rejection phenomenon usually occurs about 7 days after transplantation. There have been many challengers and reports about possible prolongation of homograft, but ao fationating results had obtained. The authors investigate the effect of anticancer drugs and immunosuppressive drugs to the skin homograft in mice and the results summerized as followings.
1. Control group of hemograft survived for 7-11 days.
2. Mice treated with Mytomicin survived for 17.5 days, 5FU was 16.1 days, prednysolone was 18.2 days and Endoxan was 17.2 days.
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